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Returning withFire and Blood, theGame of Thronesfranchise has witnessed a revival with its spin-off show,House of the Dragon. It follows the Targaryen conflict, around 200 years before the events ofGame of Thrones, focusing on KingViserys Targaryen and Prince Daemon Targaryen.

Related:Internet Warms up to House of the Dragon Despite Bad Initial Reviews: Game of Thrones Prequel Makes History, Breaks Yet Another Record in the UK
The show is expected to cascade into a bloody civil war, as was in the case ofGame of Thrones. It stars Matt Smith as the impulsive and violentPrince Daemon Targaryenwho rides the Blood Wyrm dragon, Caraxes.

Spoilers ahead
What is greyscale?
Greyscale is a disease that is usually deadly and communicable on contact. It leaves a layer of stiff and dead skin at the top which feels like stone on touch. InGame of Thrones, Shireen Baratheon had caught greyscale but survived it, leaving her disfigured.
It was also confirmed in the books that there are different versions of greyscale, with Shireen Baratheon actually having the dormant kind. The dormant kind only leaves the victim disfigured but doesn’t kill them, also is not contagious.

Also read:House of the Dragon Theory: Otto Hightower is Working With the Maesters To Kill King Viserys
https://twitter.com/Jazzyruf/status/1567210933558169609

At the end of the third episode ofHouse of the Dragon,Daemon Targaryenkilled the Crabfeeder and dragged his corpse into the battlefield, seemingly victorious. But the Crabfeeder also had greyscale across his body, leaving many viewers questioning whether the Prince caught it too.
DidDaemon Targaryencatch greyscale?
Since Daemon Targaryen had touched the Crabfeeder’s infected hand, it seems like he was infected with greyscale. On the other hand, since the disease can be a dormant variant, some argued that the Crab King’s greyscale was dormant too.
so shouldn’t daemon have it now that he was basically covered in his guts?

— w 🩸 (@afc__98)June 20, 2025
Check out:‘He’s really angry…super ambitious’: House of the Dragon Star Steve Toussaint Hints Corlys Velaryon Could Be the First Black Man To Sit on the Iron Throne
Daemon dragged Craghas Drahar into the Battlefield, Craghas has Greyscale same disease as Shireen Baratheon and Jorah Mormont.pic.twitter.com/jMYfwSX9Md
— House of the Dragon • Game of Thrones (@gotandmore)August 11, 2025
RIP Crabfeeder. Please don’t give Daemon greyscale.#HouseOfTheDragonpic.twitter.com/s5pMB4UQmO
— New Rockstars (@NewRockstars)July 18, 2025
Read more:House of the Dragon vs. Game of Thrones: Is Rhaenyra a Better Dragon Queen Than Daenerys Targaryen
Are Targaryens immune to disease? Cuz Daemon was sure touching that greyscale
— Mj (@ThisGrayArea)August 14, 2025
Furthermore, fans have also argued that Targaryens might be immune to greyscale, due to their dragon blood and magical origins. Also, plot armor also needs to be addressed, the show wouldn’t kill off such an important character who’s built up to play a bigger role in future episodes.
House of the Dragonis currently streaming on HBO Max.
Source:Twitter
Nikhil Makwana
Articles Published :270
Nikhil Makwana is a writer for FandomWire, with interests in DC comics, anime, indie films, independent films, and Nicolas Cage. He’s pursuing a Bachelor’s degree in BBA,LLB from IFIM Law School. When he’s not writing, he reads books such as the classic Dune series and existential essays from Albert Camus and Jean-Paul Sartre.